A research plan has been developed in the present study to address the problems associated with Avaranajanya Madhumeha (type 2 diabetes). This research plan is based on the treatment methods of Ayurveda (ancient Indian medicine) and utilization of modern scientific methods as research tools. A specific ayurvedic herbo-mineral formulation has been prepared in Ghansatt (solid extract) form; the selected eight herbs and one herbo-mineral have anti-hyperglycemic (PRAMEHA HARA) and antihypercholestermic (MEDOHARA) properties with rejuvenative (RASAYANA) effects as described in classical ayurvedic methods. 15 diagnosed type II diabetes mellitus patients were selected through accidental sampling. Ayurvedic formulation was prescribed to type II diabetes patients for one year along with dietary restrictions. Diabetic diagnostic parameters of these patients like Fasting Blood Sugar (FBS), Post Patrum Blood Sugar (PPBS), Glycocylated Hemoglobin (HbA1C) and Urine Sugar Fasting were monitored every three months; these were measured before and after intervention. The obtained data were statistically analyzed through paired t-test. There was significant reduction in FBS level, PPBS level, HbA1C level and urine fasting sugar level in type 2 diabetes patients who completed the clinical trial successfully. Thus, ayurvedic formulation treatment lead to an overall significant reduction in blood sugar and urine sugar levels in type II diabetes patients. No side effects were noted during the study period. This study suggests that the ayurvedic formulation had very good hypoglycemic effects proved by clinical improvement and bio-chemical analysis of diabetes parameters in the treatment of type II diabetes mellitus.
American Diabetes Association (2006) Diagnosis and classification of diabetes mellitus. Diabetes Care, 29(1), 43-48.
American Diabetes Association (2008) Total Prevalence of Diabetes and Pre-diabetes. http://www.diabetes.org/diabetesstatistics/ prevalence.jsp/ Retrieved on 17 March 2006.
Anas, M., Mohsin, M., Siddiqui, M. & Mannan, A. (2011) Therapeutic evaluation of a polyherbal formulation in type 2 diabetes mellitus. Indian Journal of Traditional Knowledge, 10(4), 711-715.
Arun, N. & Nalini, N. (2002) Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Human Nutritio, 57(1), 41-52. https://doi.org/10.1023/A:1013106527829
Bhaskaran, K. M., Ahamath, B. K., Shanmugasundaram, K. R. & Shanmugasundaram, E. R. (1990) Anti-diabetic effects of a leaf extract from Gymnena sylvestre in NIDDM patients. Journal ofEthanopharmacol, 30, 295 https://doi.org/10.1016/0378-8741(90)90108-6
Bhattacharya, A., Chatterjee, A., Ghosal, S. & Bhattacharya, S.K. (1999) Antioxidant activity of active tannoid principle of Emblica officinalis. Indian Journal of Experimental Biology, 35, 297.
Boon, N.A., Colledge, N. R. & Walker, B. R. (2006) Diabetes mellitus: Davidson's principles and practice of medicine (20th Ed.). London: Elsevier. P. 805-847
Central Council for Research in Ayurveda and Siddha (2005) Data base on Medicinal Plants used in Ayurveda (vol.1). New Delhi: CCRAS.
Chakraborty, U. & Das, H. (2010) Antidiabetic and Antioxidant Activities of Cinnamomum tamala Leaf Extracts in Stz-Treated Diabetic Rats. Global Journal of Biotechnology & Biochemistry, 5(1), 12-18.
Daniel, Z. & Maria, H. (2000) Domestication of plants in the Old World (3rd ed.). Ney York, NY: Oxford University Press, p.122.
Davidson, M.B. (1991) Diabetes Mellitus: Diagnosis and Treatment (3rd ed.) New York, NY: Churchill Livingstone.
Gerstein, H. C., Miller, M. E., Byington, R. P., Goff, D. C., Bigger, J. T. & Buse, J. B. (2008) Effects of intensive glucose lowering in type 2 diabetes. New England Journal of Medicine, 358(24), 2545-59.https://doi.org/10.1056/NEJMoa0802743
Gupta, S.S., Verma, S. C., Garg, V.P. & Rai, M. (1967) Anti-diabetic effects of Tinospora cordifolia. Indian Journal of Medical Research, 55, 733.
Hadjadj, S. (2005) Test: Hemoglobin A1C. Diabetes Metabalism, 31, 290-294 https://doi.org/10.1016/S1262-3636(07)70196-9
Halim, E. M. & Ali, H. (2002) Hypoglycemic, hypolipidemic and antioxidant properties of combination of curcumin from Curcuma longa, Linn, and partially purified product from Abroma augusta, Linn. In treptozotocin induced diabetes, Indian Journal of Clinical Biochemistry, 17, 33. https://doi.org/10.1007/BF02867969
Hoskote, S. S. & Joshi, S. R. (2008) Are Indians Destined to be Diabetic? Journal of Associations of Physicians of India, 56, 225-226.
Indian council of Medical Research (2006) Assessment of Burden of NCDs. ICMR. http://www.icmr.nic.in/annual/2009- 10/english/ncd.pdf / 22 November 2012.
International Diabetes Federation (2006) Diabetes Atlas (3rd Ed.). Brussels: International Diabetes Federation. Available at http://www.eatlas.idf.org/media/ 8 September 2008.
International Diabetes Federation (2005) Global guideline for type 2 diabetes. Brussels: International Diabetes Federation.
Joy, K. L. & Kuttan, R. (1999) Anti-diabetic Activity of Picrorrhiza kurroa extract. Journal of Ethnopharmacology, 67(2),143-148 https://doi.org/10.1016/S0378-8741(98)00243-8
Kar, A., Choudhary, B. K. & Bandyopadhyay, N. G. (2003) Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. Journal of Ethnopharmacology, 84(1),105-108.
Kelly, D. E. (1995) Effects of weight loss on glucose homeostasis in NIDDM. Diabetes Reviews, 3, 366-377.
Khan, A. & Safdar, M. (2003) Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care,26, 3215-3218. https://doi.org/10.2337/diacare.26.12.3215
Mishra, B. & Chunekar, K. C. (Ed.) (1995) Sri Bhav Prakash Nighantu (10 ed.). Varanasi: Chaukhambha Bharti Academy.
Nadkarni, K. M. & Nadkarni, A. K. (1976) Indian Materia Media (3rd ed.). Mumbai: Popular Prakasan Pvt. Ltd.
Narender, T., Puri, A., Saxena, R., Bhatia, G. & Chandra, R. (2006) 4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent. Bioorganic & Medicinal Chemistry Letters,16(2), 293-296. https://doi.org/10.1016/j.bmcl.2005.10.003
Nathan, D. M., Davidson, M. B., DeFronzo, R. A., Heine, R. J., Henry, R. R., Pratley, R. & Zinman, B. (2007) Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care,30(3), 753-759. https://doi.org/10.2337/dc07-9920
Ogawa, Y. (2004) Gymnema sylvestre leaf extract: a 52-week dietary toxicity study in Wistar rats. Shokuhin Eiseigaku Zasshi, 45(1), 8-18. https://doi.org/10.3358/shokueishi.45.8
Pandey, G. (Ed.) (2004) Dravyaguna Vigyana: Properties of herbs (2nd edition). Varanasi: Chaukhambha Bharti Academy.
Parving, H. H., Gall, M. A., Skott, P., Jorgensen, H. E., Lokkegaard, H., Jorgensen, F., Nielsen, B. & Larsen, S. (1992) Prevalence and causes of albuminuria in NIDDM patients. Kidney International, 41(4), 758- 762. https://doi.org/10.1038/ki.1992.118
Prince, P. S., Kamalakkannan, N. & Menon, V. P. (2004) Antidiabetic and antihyperlipidemic effect of alcoholic Syzigium cumini seeds in alloxan induced diabetic albino rats. Journal of Ethnopharmacol, 91, 209. https://doi.org/10.1016/j.jep.2003.11.001
Puri, H. S. (2006) Ayurvedic Minerals for Longevity. Delhi: India Book House.
Rema, M., Premkumar, S., Anitha, B., Deepa, R., Pradeepa, R. & Mohan, V. (2005) Prevalence of diabetic retinopathy in Urban India: the Chennai Urban Rural Epidemiological Study (CURES) eye study. Investigative Ophthalmology & Visual Science, 46, 22328-33. https://doi.org/10.1167/iovs.05-0019
Saxena, A. M., Mukherjee, S. K. & Shukla, G. (2006) Progress of diabetes research in India during 20th century. New Delhi: National Institute of Science and Communication.
Saxena, N., Dwivedi, U. N., Singh, R.K., Kumar, A., Saxena, C., Saxena, R.C. & Saxena, M. (2003) Modulation of oxidative and antioxidative status in diabetes by Asphaltum panjabinum. Diabetes Care, 26, 2469-2470. https://doi.org/10.2337/diacare.26.8.2469-a
Shah, S. N. (ed.) (2003) API Text Book of Medicine (7th ed.). Mumbai: API
Shani, J., Goldsehmied, A., Joseph, B., Ahronson, Z. & Sulman, F. G. (1974) Hypoglycaemie effect of Trigonella foenum graecum seeds and their major alkaloids in alloxan diabetic and normal rats. Archives International Pharmaceutical Therapy, 210, 27-37.
Sharma P. V. (ed.) (2001) Charak Samhita of Agnivesha (6th. Edition). Varanasi: Chaukhambha Publications.
Sharma, P. V. (1983) Charaka Samhita (Vol. II). Varanasi: Chaukhamba Orientalia.
Sharma, P.V. (2002) Chakradatta of Chakrapanidatta. Varanasi: Chaukhamba Publications, p. 327. https://doi.org/10.1023/A:1020319404982
Shastri, A. D. (1995) Sushruta Samhita (9th Ed.). Varanasi: Chaukhambha Publications, p. 251-252.
Shukla, V.D., & Tripathi, R. D. (Ed.) (2002) Charaka Samhita. Delhi : Chaukhamba Sanskrit Pratishthana.
Sulman, F. G. & Menczel, E. (1962) Harokeach Haire (9:6). Chemical Abstract 57, 11308e.
Trider, P. A. (1969) Glucose was determined by using the enzymatic method (GOD-POD). Clinical Biochemistry, 6, 24-33.
Trivedi, N. A., Mazumdar, B., Bhatt, J. D. & Hemavathi, K. G. (2004) Effect of shilajit on blood glucose and lipid profile in alloxan induced diabetic rats. Indian Journal of Pharmacology,36(6), 373-376. World Health Organization (1999) Definition, diagnosis and classification of diabetes mellitus and itscomplications (Part 1). Geneva: WHO Sarva ev pramehastu kalena pratikurvatah, Madhumehatvamayanti tad asadhya bhavantihi.
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